The role of systemic inflammatory and nutritional blood-borne markers in predicting response to neoadjuvant chemotherapy and survival in oesophagogastric cancer

The aim of this study was to interrogate whether blood-borne inflammatory and nutritional markers predict long-term survival and response to neoadjuvant chemotherapy in radically treated oesophagogastric cancer patients. This retrospective study included 246 patients who underwent oesophageal resect...

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Veröffentlicht in:	Medical oncology (Northwood, London, England) London, England), 2013-09, Vol.30 (3), p.596-596, Article 596
Hauptverfasser:	Noble, Fergus, Hopkins, James, Curtis, Nathan, Kelly, Jamie J., Bailey, Ian S., Byrne, James P., Bateman, Adrian C., Bateman, Andrew R., Underwood, Timothy J.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Aged Aged, 80 and over Albumins - metabolism Biomarkers - metabolism Carcinoma - metabolism Carcinoma - mortality Carcinoma - pathology Disease-Free Survival Esophageal Neoplasms - metabolism Esophageal Neoplasms - mortality Esophageal Neoplasms - pathology Female Hematology Humans Inflammation - metabolism Inflammation - pathology Internal Medicine Lymphocytes - metabolism Lymphocytes - pathology Male Medicine Medicine & Public Health Middle Aged Neoadjuvant Therapy - methods Neoplasm Invasiveness - pathology Neutrophils - metabolism Neutrophils - pathology Oncology Original Paper Pathology Prognosis Retrospective Studies Stomach Neoplasms - metabolism Stomach Neoplasms - mortality Stomach Neoplasms - pathology
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Beschreibung
Zusammenfassung:	The aim of this study was to interrogate whether blood-borne inflammatory and nutritional markers predict long-term survival and response to neoadjuvant chemotherapy in radically treated oesophagogastric cancer patients. This retrospective study included 246 patients who underwent oesophageal resection for high-grade dysplasia or carcinoma between 2005 and 2010. The predictive value of routine preoperative immunonutritional blood tests was assessed for their association with survival and response to chemotherapy. On multivariate analysis, higher neutrophil–lymphocyte ratio (NLR) ( p
ISSN:	1357-0560 1559-131X
DOI:	10.1007/s12032-013-0596-6