Increased phospholipid methylation in the myocardium of alcoholic rats

Phospholipid methyltransferase activity is unevenly distributed throughout the contractile and the specialized regions of rat heart. Chronic alcohol treatment stimulated the incorporation of [ 3H-methyl]-methionine but not [ 3H-methyl]-choline into phosphatidylcholine by left ventricular slices. The...

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Veröffentlicht in:	Biochemical and biophysical research communications 1983-03, Vol.111 (2), p.710-716
Hauptverfasser:	Prasad, Chandan, Edwards, Ruth M.
Format:	Artikel
Sprache:	eng
Schlagworte:	Alcoholism - metabolism Animals Calcium - metabolism Calcium-Transporting ATPases - metabolism Humans Male Methylation Methyltransferases - metabolism Myocardium - metabolism Phosphatidyl-N-Methylethanolamine N-Methyltransferase Phosphatidylcholines - biosynthesis Phosphatidylethanolamine N-Methyltransferase Phospholipids - metabolism Rats Rats, Inbred Strains
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Beschreibung
Zusammenfassung:	Phospholipid methyltransferase activity is unevenly distributed throughout the contractile and the specialized regions of rat heart. Chronic alcohol treatment stimulated the incorporation of [ 3H-methyl]-methionine but not [ 3H-methyl]-choline into phosphatidylcholine by left ventricular slices. The increase in the incorporation of [ 3H-methyl]-group from [ 3H-methyl]-methionine into phosphatidylcholine was due to an increase in phospholipid methyltransferase activity.
ISSN:	0006-291X 1090-2104
DOI:	10.1016/0006-291X(83)90363-7