Proteomics imaging and the kidney

Proteomics imaging and the kidney

Matrix-assisted laser desorption/ionization (MALDI) and mass spectrometry (MS) imaging are advanced technologies capable of revealing the spatial distribution of different molecules--e.g., drugs and their metabolites, endogenous lipids and complex peptides/proteins--directly in tissue specimens at t...

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Veröffentlicht in:Journal of nephrology 2013-05, Vol.26 (3), p.430-436
Hauptverfasser: Magni, Fulvio, Lalowski, Maciej, Mainini, Veronica, Marchetti-Deschmann, Martina, Chinello, Clizia, Urbani, Andrea, Baumann, Marc
Format: Artikel
Sprache:eng
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Animals
Humans
Kidney - chemistry
Molecular Imaging - methods
Proteomics - methods
Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization
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container_end_page 436
container_issue 3
container_start_page 430
container_title Journal of nephrology
container_volume 26
creator Magni, Fulvio
Lalowski, Maciej
Mainini, Veronica
Marchetti-Deschmann, Martina
Chinello, Clizia
Urbani, Andrea
Baumann, Marc
description Matrix-assisted laser desorption/ionization (MALDI) and mass spectrometry (MS) imaging are advanced technologies capable of revealing the spatial distribution of different molecules--e.g., drugs and their metabolites, endogenous lipids and complex peptides/proteins--directly in tissue specimens at the same time. Information obtained regarding tissues by MALDI profiling/imaging analysis can be correlated with other MS-based techniques, auxiliary imaging technologies and routine immunohistochemical stainings. In this review we describe the MALDI profiling/imaging technologies, providing examples of their application in kidney research.
doi_str_mv 10.5301/jn.5000243
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source MEDLINE; EZB-FREE-00999 freely available EZB journals; Alma/SFX Local Collection
subjects Animals
Humans
Kidney - chemistry
Molecular Imaging - methods
Proteomics - methods
Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization
title Proteomics imaging and the kidney
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