Proteomics imaging and the kidney

Matrix-assisted laser desorption/ionization (MALDI) and mass spectrometry (MS) imaging are advanced technologies capable of revealing the spatial distribution of different molecules--e.g., drugs and their metabolites, endogenous lipids and complex peptides/proteins--directly in tissue specimens at t...

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Veröffentlicht in:Journal of nephrology 2013-05, Vol.26 (3), p.430-436
Hauptverfasser: Magni, Fulvio, Lalowski, Maciej, Mainini, Veronica, Marchetti-Deschmann, Martina, Chinello, Clizia, Urbani, Andrea, Baumann, Marc
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Sprache:eng
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Zusammenfassung:Matrix-assisted laser desorption/ionization (MALDI) and mass spectrometry (MS) imaging are advanced technologies capable of revealing the spatial distribution of different molecules--e.g., drugs and their metabolites, endogenous lipids and complex peptides/proteins--directly in tissue specimens at the same time. Information obtained regarding tissues by MALDI profiling/imaging analysis can be correlated with other MS-based techniques, auxiliary imaging technologies and routine immunohistochemical stainings. In this review we describe the MALDI profiling/imaging technologies, providing examples of their application in kidney research.
ISSN:1121-8428
1724-6059
DOI:10.5301/jn.5000243