Association of parity with osteoprotegerin levels and atherosclerosis

Purpose Association of serum osteoprotegerin (OPG) levels and cardiovascular disorders has been shown previously. The aim of this observational study was to investigate the relationship between parity, OPG and carotid intima-media thickness (CIMT) in premenopausal women. Methods A total of 128 women...

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Veröffentlicht in:	Archives of gynecology and obstetrics 2013-06, Vol.287 (6), p.1081-1086
Hauptverfasser:	Eren, Mehmet Ali, Vural, Mehmet, Yildiz, Sema, Cece, Hasan, Camuzcuoglu, Hakan, Toy, Harun, Kocyigit, Abdurrahim
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Atherosclerosis Atherosclerosis - diagnosis Atherosclerosis - diagnostic imaging Body Mass Index Carotid Intima-Media Thickness Endocrinology Female Gynecology Human Genetics Humans Maternal-Fetal Medicine Medicine Medicine & Public Health Obstetrics/Perinatology/Midwifery Osteoprotegerin - blood Parity - physiology Pregnancy Premenopause Risk Factors
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Zusammenfassung:	Purpose Association of serum osteoprotegerin (OPG) levels and cardiovascular disorders has been shown previously. The aim of this observational study was to investigate the relationship between parity, OPG and carotid intima-media thickness (CIMT) in premenopausal women. Methods A total of 128 women (mean age ± SD, 37.8 ± 4.7 years) were divided into three group according to parity [1–3 as group 1 ( n = 41), 4–6 as group 2 ( n = 55) and ≥7 as group 3 ( n = 32)]. Serum OPG was measured and CIMT was evaluated. Results Both serum OPG levels and CIMT tended to increase with advancing parity; OPG level was significantly higher in group 3 than in group 1 ( p = 0.013) and CIMT was significantly higher in group 2 and group 3 than in group 1 ( p
ISSN:	0932-0067 1432-0711
DOI:	10.1007/s00404-012-2703-x