Trypanosoma cruzi trans-sialidase initiates a program independent of the transcription factors RORγt and Ahr that leads to IL-17 production by activated B cells
Antibody production is the main effector function of B cells. Rawlings and colleagues show that Trypanosome cruzi induces rapid IL-17 production by B cells that is required for parasite control. Here we identified B cells as a major source of rapid, innate-like production of interleukin 17 (IL-17) i...
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Veröffentlicht in: | Nature immunology 2013-05, Vol.14 (5), p.514-522 |
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Sprache: | eng |
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Zusammenfassung: | Antibody production is the main effector function of B cells. Rawlings and colleagues show that
Trypanosome cruzi
induces rapid IL-17 production by B cells that is required for parasite control.
Here we identified B cells as a major source of rapid, innate-like production of interleukin 17 (IL-17)
in vivo
in response to infection with
Trypanosoma cruzi
. IL-17
+
B cells had a plasmablast phenotype, outnumbered cells of the T
H
17 subset of helper T cells and were required for an optimal response to this pathogen. With both mouse and human primary B cells, we found that exposure to parasite-derived trans-sialidase
in vitro
was sufficient to trigger modification of the cell-surface mucin CD45, which led to signaling dependent on the kinase Btk and production of IL-17A or IL-17F via a transcriptional program independent of the transcription factors RORγt and Ahr. Our combined data suggest that the generation of IL-17
+
B cells may be a previously unappreciated feature of innate immune responses required for pathogen control or IL-17-mediated autoimmunity. |
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ISSN: | 1529-2908 1529-2916 |
DOI: | 10.1038/ni.2569 |