Replication and meta-analysis of common variants identifies a genome-wide significant locus in migraine

Background and purpose Genetic factors contribute to the aetiology of the prevalent form of migraine without aura (MO) and migraine with typical aura (MTA). Due to the complex inheritance of MO and MTA, the genetic background is still not fully established. In a population‐based genome‐wide associat...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	European journal of neurology 2013-05, Vol.20 (5), p.765-772
Hauptverfasser:	Esserlind, A.-L., Christensen, A. F., Le, H., Kirchmann, M., Hauge, A. W., Toyserkani, N. M., Hansen, T., Grarup, N., Werge, T., Steinberg, S., Bettella, F., Stefansson, H., Olesen, J.
Format:	Artikel
Sprache:	eng
Schlagworte:	Alleles Case-Control Studies European Continental Ancestry Group - genetics Genetic factors Genetic Predisposition to Disease - genetics genome-wide association studies Genome-Wide Association Study Humans Low Density Lipoprotein Receptor-Related Protein-1 - genetics meta-analysis migraine Migraine Disorders - genetics migraine-genetics Nerve Tissue Proteins - genetics Polymorphism, Single Nucleotide - genetics Registries replication Tetraspanins - genetics TRPM Cation Channels - genetics
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Beschreibung
Zusammenfassung:	Background and purpose Genetic factors contribute to the aetiology of the prevalent form of migraine without aura (MO) and migraine with typical aura (MTA). Due to the complex inheritance of MO and MTA, the genetic background is still not fully established. In a population‐based genome‐wide association study by Chasman et al. (Nat Genet 2011: 43: 695–698), three common variants were found to confer risk of migraine at a genome‐wide significant level (P
ISSN:	1351-5101 1468-1331
DOI:	10.1111/ene.12055