Increase of N1,N12-diacetylspermine in tissues from colorectal cancer and its liver metastasis

Purpose N 1 ,N 12 -Diacetylspermine (DiAcSpm) is a tumor marker featured by increase in the urine of patients with cancers, including early colorectal cancer, but where and how DiAcSpm is made remains unclear. We aimed to clarify whether colorectal cancer tissues produce increased amounts of DiAcSpm...

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Veröffentlicht in:	Journal of cancer research and clinical oncology 2013-06, Vol.139 (6), p.925-932
Hauptverfasser:	Kuwata, Go, Hiramatsu, Kyoko, Samejima, Keijiro, Iwasaki, Kaori, Takahashi, Kei-ichi, Koizumi, Koichi, Horiguchi, Shin-ichiro, Moriya, Shun-suke, Kobayashi, Masaki, Kawakita, Masao
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Aged Aged, 80 and over Antineoplastic agents Biological and medical sciences Biomarkers, Tumor - metabolism Cancer Research Chromatography, High Pressure Liquid Colorectal Neoplasms - metabolism Colorectal Neoplasms - pathology Female Gastroenterology. Liver. Pancreas. Abdomen Hematology Humans Internal Medicine Liver Neoplasms - metabolism Liver Neoplasms - secondary Liver. Biliary tract. Portal circulation. Exocrine pancreas Male Mass Spectrometry Medical sciences Medicine Medicine & Public Health Middle Aged Multiple tumors. Solid tumors. Tumors in childhood (general aspects) Neoplasm Staging Oncology Original Paper Pharmacology. Drug treatments Precancerous Conditions - metabolism Precancerous Conditions - pathology Spermine - analogs & derivatives Spermine - metabolism Stomach. Duodenum. Small intestine. Colon. Rectum. Anus Tumors
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Zusammenfassung:	Purpose N 1 ,N 12 -Diacetylspermine (DiAcSpm) is a tumor marker featured by increase in the urine of patients with cancers, including early colorectal cancer, but where and how DiAcSpm is made remains unclear. We aimed to clarify whether colorectal cancer tissues produce increased amounts of DiAcSpm, and if they do, to examine whether tissue DiAcSpm level may serve as a criterion of tissue malignancy. Methods Tissue samples were obtained from 140 patients (13 low-grade intraepithelial neoplasia, 98 high-grade intraepithelial neoplasia and 29 colorectal cancer) treated for colorectal cancer and intraepithelial neoplasia at Tokyo Metropolitan Komagome Hospital between November 2007 and April 2011. The DiAcSpm level in cancer and adjacent normal tissue extracts was compared, and its relationship with clinical stages of the diseases was analyzed. Results DiAcSpm levels were higher in colorectal cancer tissue ( p
ISSN:	0171-5216 1432-1335
DOI:	10.1007/s00432-013-1405-5