Clinical Prognostic Factors for Survival and Risk of Progression to Acute Myeloid Leukemia in Patients With Myelodysplastic Syndromes With < 10% Marrow Blasts and Non-Unfavorable Cytogenetic Categories

Micro-Abstract Prognosis of myelodysplastic syndromes (MDS) is an area of ongoing interest. Identification of patients with poor outcome in the categories of lower risk disease is critical. In this study, we classify a cohort of 332 lower risk MDS into 3 groups with differences in survival and risk...

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Veröffentlicht in:	Clinical lymphoma, myeloma and leukemia myeloma and leukemia, 2013-04, Vol.13 (2), p.144-152
Hauptverfasser:	Falantes, Jose F, Calderón, Cristina, Márquez Malaver, Francisco J, Alonso, Dora, Martín Noya, Antonio, Carrillo, Estrella, Martino, María L, Montero, Isabel, González, Jose, Parody, Rocío, Espigado, Ildefonso, Pérez-Simón, Jose A
Format:	Artikel
Sprache:	eng
Schlagworte:	Adolescent Adult Aged Aged, 80 and over Bone Marrow Cells - pathology Chromosome Aberrations Disease Progression Female Hematology, Oncology and Palliative Medicine Humans Karyotype Leukemia, Myeloid, Acute - etiology Leukemia, Myeloid, Acute - mortality Male Middle Aged Myelodysplasia Myelodysplastic Syndromes - diagnosis Myelodysplastic Syndromes - mortality Outcome Prognosis Scoring system Young Adult
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Zusammenfassung:	Micro-Abstract Prognosis of myelodysplastic syndromes (MDS) is an area of ongoing interest. Identification of patients with poor outcome in the categories of lower risk disease is critical. In this study, we classify a cohort of 332 lower risk MDS into 3 groups with differences in survival and risk for leukemic progression that could drive treatment approaches to improve prognosis in a fraction of these patients.
ISSN:	2152-2650 2152-2669
DOI:	10.1016/j.clml.2012.09.013