The Cytotoxicity of Duocarmycin Analogues is Mediated through Alkylation of DNA, not Aldehyde Dehydrogenase 1: A Comment

The answer lies in the DNA: Recent claims that the alkylation of a particular protein contributes to the cytotoxicity of the duocarmycins could not be substantiated. The evidence, like the fluorescent signal derived from a clickable analogue, points instead to a reaction occurring in the nucleus.

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Bibliographische Detailangaben
Veröffentlicht in:	Angewandte Chemie International Edition 2013-05, Vol.52 (21), p.5442-5446
Hauptverfasser:	Tercel, Moana, McManaway, Sarah P., Leung, Euphemia, Liyanage, H. D. Sarath, Lu, Guo-Liang, Pruijn, Frederik B.
Format:	Artikel
Sprache:	eng
Schlagworte:	activity-based protein profiling antitumor agents biological activity DNA damage duocarmycin Humans Isoenzymes - antagonists & inhibitors Retinal Dehydrogenase - antagonists & inhibitors
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Beschreibung
Zusammenfassung:	The answer lies in the DNA: Recent claims that the alkylation of a particular protein contributes to the cytotoxicity of the duocarmycins could not be substantiated. The evidence, like the fluorescent signal derived from a clickable analogue, points instead to a reaction occurring in the nucleus.
ISSN:	1433-7851 1521-3773
DOI:	10.1002/anie.201208373