Role of Nitric Oxide in the Pathogenesis of Alloxan Diabetes
We studied the effects of N ω -nitro-L-arginine (L-NNA), a nonselective inhibitor of NO synthases, on the severity of type 1 diabetes mellitus induced by subcutaneous injection of 130 mg/kg alloxan in August rats with high activity of NO system and in Wistar rats. Five days after alloxan injection,...
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| Veröffentlicht in: | Bulletin of experimental biology and medicine 2013-03, Vol.154 (5), p.602-605 |
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| container_title | Bulletin of experimental biology and medicine |
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| creator | Belkina, L. M. Smirnova, E. A. Terekhina, O. L. Kruglov, S. V. Boichuk, E. S. |
| description | We studied the effects of N
ω
-nitro-L-arginine (L-NNA), a nonselective inhibitor of NO synthases, on the severity of type 1 diabetes mellitus induced by subcutaneous injection of 130 mg/kg alloxan in August rats with high activity of NO system and in Wistar rats. Five days after alloxan injection, hyperglycemia levels after overnight fasting in August and Wistar rats were 27.1±3.7 and 22.0±1.1 mmol/liter, respectively (
p |
| doi_str_mv | 10.1007/s10517-013-2009-4 |
| format | Article |
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ω
-nitro-L-arginine (L-NNA), a nonselective inhibitor of NO synthases, on the severity of type 1 diabetes mellitus induced by subcutaneous injection of 130 mg/kg alloxan in August rats with high activity of NO system and in Wistar rats. Five days after alloxan injection, hyperglycemia levels after overnight fasting in August and Wistar rats were 27.1±3.7 and 22.0±1.1 mmol/liter, respectively (
p
<0.03). The mortality over 15 days after alloxan injection in August rats was higher than in Wistar rats (36 and 26%, respectively). L-NNA normalized glucose levels in diabetics of both groups. It completely prevented mortality in August and reduced it to 13% in Wistar rats. Body weight loss and polydipsia after LNNA injection were also less pronounced in August rats. Plasma nitrite/nitrate concentrations in August rats were 32% higher than in Wistar rats, both in intact and diabetic rats. These data attest to an important role of NO in the pathogenesis of alloxan diabetes.</description><identifier>ISSN: 0007-4888</identifier><identifier>EISSN: 1573-8221</identifier><identifier>DOI: 10.1007/s10517-013-2009-4</identifier><identifier>PMID: 23658878</identifier><identifier>CODEN: BEXBAN</identifier><language>eng</language><publisher>Boston: Springer US</publisher><subject>Alloxan ; Animals ; Biomedical and Life Sciences ; Biomedicine ; Blood Glucose - analysis ; Body weight ; Cell Biology ; Dextrose ; Diabetes Mellitus, Experimental - metabolism ; Diabetes Mellitus, Experimental - prevention & control ; Diabetics ; Enzyme Inhibitors - therapeutic use ; Glucose ; Glucose metabolism ; Health aspects ; Hyperglycemia ; Internal Medicine ; Laboratory Medicine ; Male ; Nitrates - blood ; Nitric oxide ; Nitric Oxide - biosynthesis ; Nitric Oxide - physiology ; Nitric Oxide Synthase - antagonists & inhibitors ; Nitrites - blood ; Nitroarginine - therapeutic use ; Pathology ; Pyrimidines ; Rats ; Rats, Inbred Strains ; Rats, Wistar ; Type 1 diabetes</subject><ispartof>Bulletin of experimental biology and medicine, 2013-03, Vol.154 (5), p.602-605</ispartof><rights>Springer Science+Business Media New York 2013</rights><rights>COPYRIGHT 2013 Springer</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c470t-d511f09d980fe66013fe35903ebfc34fff37c9399bddf5f3ec017dfb9db848b3</citedby><cites>FETCH-LOGICAL-c470t-d511f09d980fe66013fe35903ebfc34fff37c9399bddf5f3ec017dfb9db848b3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s10517-013-2009-4$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s10517-013-2009-4$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,780,784,27924,27925,41488,42557,51319</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/23658878$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Belkina, L. M.</creatorcontrib><creatorcontrib>Smirnova, E. A.</creatorcontrib><creatorcontrib>Terekhina, O. L.</creatorcontrib><creatorcontrib>Kruglov, S. V.</creatorcontrib><creatorcontrib>Boichuk, E. S.</creatorcontrib><title>Role of Nitric Oxide in the Pathogenesis of Alloxan Diabetes</title><title>Bulletin of experimental biology and medicine</title><addtitle>Bull Exp Biol Med</addtitle><addtitle>Bull Exp Biol Med</addtitle><description>We studied the effects of N
ω
-nitro-L-arginine (L-NNA), a nonselective inhibitor of NO synthases, on the severity of type 1 diabetes mellitus induced by subcutaneous injection of 130 mg/kg alloxan in August rats with high activity of NO system and in Wistar rats. Five days after alloxan injection, hyperglycemia levels after overnight fasting in August and Wistar rats were 27.1±3.7 and 22.0±1.1 mmol/liter, respectively (
p
<0.03). The mortality over 15 days after alloxan injection in August rats was higher than in Wistar rats (36 and 26%, respectively). L-NNA normalized glucose levels in diabetics of both groups. It completely prevented mortality in August and reduced it to 13% in Wistar rats. Body weight loss and polydipsia after LNNA injection were also less pronounced in August rats. Plasma nitrite/nitrate concentrations in August rats were 32% higher than in Wistar rats, both in intact and diabetic rats. These data attest to an important role of NO in the pathogenesis of alloxan diabetes.</description><subject>Alloxan</subject><subject>Animals</subject><subject>Biomedical and Life Sciences</subject><subject>Biomedicine</subject><subject>Blood Glucose - analysis</subject><subject>Body weight</subject><subject>Cell Biology</subject><subject>Dextrose</subject><subject>Diabetes Mellitus, Experimental - metabolism</subject><subject>Diabetes Mellitus, Experimental - prevention & control</subject><subject>Diabetics</subject><subject>Enzyme Inhibitors - therapeutic use</subject><subject>Glucose</subject><subject>Glucose metabolism</subject><subject>Health aspects</subject><subject>Hyperglycemia</subject><subject>Internal Medicine</subject><subject>Laboratory Medicine</subject><subject>Male</subject><subject>Nitrates - blood</subject><subject>Nitric oxide</subject><subject>Nitric Oxide - biosynthesis</subject><subject>Nitric Oxide - physiology</subject><subject>Nitric Oxide Synthase - antagonists & inhibitors</subject><subject>Nitrites - blood</subject><subject>Nitroarginine - therapeutic use</subject><subject>Pathology</subject><subject>Pyrimidines</subject><subject>Rats</subject><subject>Rats, Inbred Strains</subject><subject>Rats, Wistar</subject><subject>Type 1 diabetes</subject><issn>0007-4888</issn><issn>1573-8221</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2013</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNp1kVFrFTEQhYNY7LX6A3yRBUH6snWyye4m4MulVlsoVqTvIZtM7k3J3dRkF-q_N8ut2hYlDyGT7xxm5hDyhsIJBeg_ZAot7WugrG4AZM2fkRVte1aLpqHPyQoKVHMhxCF5mfPN8oSOviCHDetaIXqxIh-_x4BVdNVXPyVvqqs7b7HyYzVtsfqmp23c4IjZ54VZhxDv9Fh98nrACfMrcuB0yPj6_j4i15_Prk_P68urLxen68va8B6m2raUOpBWCnDYdaVdh6yVwHBwhnHnHOuNZFIO1rrWMTRAe-sGaQfBxcCOyPHe9jbFHzPmSe18NhiCHjHOWVHWAuWSgyjouyfoTZzTWJpTlFPGoRG8_UttdEDlRxenpM1iqtaMCWCCiq5QJ_-gyrG48yaO6HypPxK8fyDYog7TNscwTz6O-TFI96BJMeeETt0mv9Ppp6KglmTVPllVVqWWZBUvmrf3k83DDu0fxe8oC9DsgVy-xg2mB6P_1_UXJ0upyw</recordid><startdate>20130301</startdate><enddate>20130301</enddate><creator>Belkina, L. M.</creator><creator>Smirnova, E. A.</creator><creator>Terekhina, O. L.</creator><creator>Kruglov, S. V.</creator><creator>Boichuk, E. 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M. ; Smirnova, E. A. ; Terekhina, O. L. ; Kruglov, S. V. ; Boichuk, E. S.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c470t-d511f09d980fe66013fe35903ebfc34fff37c9399bddf5f3ec017dfb9db848b3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2013</creationdate><topic>Alloxan</topic><topic>Animals</topic><topic>Biomedical and Life Sciences</topic><topic>Biomedicine</topic><topic>Blood Glucose - analysis</topic><topic>Body weight</topic><topic>Cell Biology</topic><topic>Dextrose</topic><topic>Diabetes Mellitus, Experimental - metabolism</topic><topic>Diabetes Mellitus, Experimental - prevention & control</topic><topic>Diabetics</topic><topic>Enzyme Inhibitors - therapeutic use</topic><topic>Glucose</topic><topic>Glucose metabolism</topic><topic>Health aspects</topic><topic>Hyperglycemia</topic><topic>Internal Medicine</topic><topic>Laboratory Medicine</topic><topic>Male</topic><topic>Nitrates - blood</topic><topic>Nitric oxide</topic><topic>Nitric Oxide - biosynthesis</topic><topic>Nitric Oxide - physiology</topic><topic>Nitric Oxide Synthase - antagonists & inhibitors</topic><topic>Nitrites - blood</topic><topic>Nitroarginine - therapeutic use</topic><topic>Pathology</topic><topic>Pyrimidines</topic><topic>Rats</topic><topic>Rats, Inbred Strains</topic><topic>Rats, Wistar</topic><topic>Type 1 diabetes</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Belkina, L. 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M.</au><au>Smirnova, E. A.</au><au>Terekhina, O. L.</au><au>Kruglov, S. V.</au><au>Boichuk, E. S.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Role of Nitric Oxide in the Pathogenesis of Alloxan Diabetes</atitle><jtitle>Bulletin of experimental biology and medicine</jtitle><stitle>Bull Exp Biol Med</stitle><addtitle>Bull Exp Biol Med</addtitle><date>2013-03-01</date><risdate>2013</risdate><volume>154</volume><issue>5</issue><spage>602</spage><epage>605</epage><pages>602-605</pages><issn>0007-4888</issn><eissn>1573-8221</eissn><coden>BEXBAN</coden><abstract>We studied the effects of N
ω
-nitro-L-arginine (L-NNA), a nonselective inhibitor of NO synthases, on the severity of type 1 diabetes mellitus induced by subcutaneous injection of 130 mg/kg alloxan in August rats with high activity of NO system and in Wistar rats. Five days after alloxan injection, hyperglycemia levels after overnight fasting in August and Wistar rats were 27.1±3.7 and 22.0±1.1 mmol/liter, respectively (
p
<0.03). The mortality over 15 days after alloxan injection in August rats was higher than in Wistar rats (36 and 26%, respectively). L-NNA normalized glucose levels in diabetics of both groups. It completely prevented mortality in August and reduced it to 13% in Wistar rats. Body weight loss and polydipsia after LNNA injection were also less pronounced in August rats. Plasma nitrite/nitrate concentrations in August rats were 32% higher than in Wistar rats, both in intact and diabetic rats. These data attest to an important role of NO in the pathogenesis of alloxan diabetes.</abstract><cop>Boston</cop><pub>Springer US</pub><pmid>23658878</pmid><doi>10.1007/s10517-013-2009-4</doi><tpages>4</tpages></addata></record> |
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| subjects | Alloxan Animals Biomedical and Life Sciences Biomedicine Blood Glucose - analysis Body weight Cell Biology Dextrose Diabetes Mellitus, Experimental - metabolism Diabetes Mellitus, Experimental - prevention & control Diabetics Enzyme Inhibitors - therapeutic use Glucose Glucose metabolism Health aspects Hyperglycemia Internal Medicine Laboratory Medicine Male Nitrates - blood Nitric oxide Nitric Oxide - biosynthesis Nitric Oxide - physiology Nitric Oxide Synthase - antagonists & inhibitors Nitrites - blood Nitroarginine - therapeutic use Pathology Pyrimidines Rats Rats, Inbred Strains Rats, Wistar Type 1 diabetes |
| title | Role of Nitric Oxide in the Pathogenesis of Alloxan Diabetes |
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