Role of Nitric Oxide in the Pathogenesis of Alloxan Diabetes

We studied the effects of N ω -nitro-L-arginine (L-NNA), a nonselective inhibitor of NO synthases, on the severity of type 1 diabetes mellitus induced by subcutaneous injection of 130 mg/kg alloxan in August rats with high activity of NO system and in Wistar rats. Five days after alloxan injection,...

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Veröffentlicht in:	Bulletin of experimental biology and medicine 2013-03, Vol.154 (5), p.602-605
Hauptverfasser:	Belkina, L. M., Smirnova, E. A., Terekhina, O. L., Kruglov, S. V., Boichuk, E. S.
Format:	Artikel
Sprache:	eng
Schlagworte:	Alloxan Animals Biomedical and Life Sciences Biomedicine Blood Glucose - analysis Body weight Cell Biology Dextrose Diabetes Mellitus, Experimental - metabolism Diabetes Mellitus, Experimental - prevention & control Diabetics Enzyme Inhibitors - therapeutic use Glucose Glucose metabolism Health aspects Hyperglycemia Internal Medicine Laboratory Medicine Male Nitrates - blood Nitric oxide Nitric Oxide - biosynthesis Nitric Oxide - physiology Nitric Oxide Synthase - antagonists & inhibitors Nitrites - blood Nitroarginine - therapeutic use Pathology Pyrimidines Rats Rats, Inbred Strains Rats, Wistar Type 1 diabetes
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Zusammenfassung:	We studied the effects of N ω -nitro-L-arginine (L-NNA), a nonselective inhibitor of NO synthases, on the severity of type 1 diabetes mellitus induced by subcutaneous injection of 130 mg/kg alloxan in August rats with high activity of NO system and in Wistar rats. Five days after alloxan injection, hyperglycemia levels after overnight fasting in August and Wistar rats were 27.1±3.7 and 22.0±1.1 mmol/liter, respectively ( p
ISSN:	0007-4888 1573-8221
DOI:	10.1007/s10517-013-2009-4