Phosphoinositide 3-kinase gamma in T cell biology and disease therapy

Phosphoinositide 3‐kinase gamma (PI3Kγ) kinase activity is important for its signaling functions in T cell development, activation, differentiation, and trafficking. Protection of PI3Kγ knockout mice from disease in multiple autoimmune models suggests that targeting PI3Kγ alone, or in combination wi...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Annals of the New York Academy of Sciences 2013-03, Vol.1280 (1), p.40-43
1. Verfasser:	Fung-Leung, Wai-Ping
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Autoimmune Diseases - drug therapy Autoimmune Diseases - metabolism Class Ib Phosphatidylinositol 3-Kinase - metabolism Disease Models, Animal disease therapy Kinases Mice Mice, Knockout Molecular Targeted Therapy PI3Kγ PI3Kγ T cells T cells T-Lymphocytes - enzymology T-Lymphocytes - metabolism
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Beschreibung
Zusammenfassung:	Phosphoinositide 3‐kinase gamma (PI3Kγ) kinase activity is important for its signaling functions in T cell development, activation, differentiation, and trafficking. Protection of PI3Kγ knockout mice from disease in multiple autoimmune models suggests that targeting PI3Kγ alone, or in combination with PI3Kδ, could be a promising approach to disease therapy.
ISSN:	0077-8923 1749-6632
DOI:	10.1111/nyas.12029