A Case of IgG4-Related Hypophysitis Without Pituitary Insufficiency

Context: IgG4-related hypophysitis is a novel clinical disease entity, which is typically complicated by hypopituitarism. Objective: The objective of the study was to describe a novel case of IgG4-related hypophysitis without pituitary insufficiency and summarize the current relevant literature. Pat...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	The journal of clinical endocrinology and metabolism 2013-05, Vol.98 (5), p.1808-1811
Hauptverfasser:	Hattori, Yujiro, Tahara, Shigeyuki, Ishii, Yudo, Kitamura, Takayuki, Inomoto, Chie, Osamura, Robert Yoshiyuki, Teramoto, Akira, Morita, Akio
Format:	Artikel
Sprache:	eng
Schlagworte:	Anti-Inflammatory Agents - therapeutic use Biological and medical sciences Endocrinopathies Feeding. Feeding behavior Fundamental and applied biological sciences. Psychology Hemianopsia - etiology Hemianopsia - prevention & control Humans Hypothalamus. Hypophysis. Epiphysis (diseases) Immunoglobulin G - analysis Male Medical sciences Middle Aged Non tumoral diseases. Target tissue resistance. Benign neoplasms Organ Size - drug effects Pituitary Diseases - drug therapy Pituitary Diseases - immunology Pituitary Diseases - pathology Pituitary Diseases - physiopathology Pituitary Gland - drug effects Pituitary Gland - immunology Pituitary Gland - pathology Pituitary Gland - physiopathology Prednisolone - therapeutic use Treatment Outcome Vertebrates: anatomy and physiology, studies on body, several organs or systems Vertebrates: endocrinology
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Beschreibung
Zusammenfassung:	Context: IgG4-related hypophysitis is a novel clinical disease entity, which is typically complicated by hypopituitarism. Objective: The objective of the study was to describe a novel case of IgG4-related hypophysitis without pituitary insufficiency and summarize the current relevant literature. Patient and Methods: A 55-year-old Japanese man presented with an enlarged pituitary gland and bitemporal hemianopsia. Endocrine studies revealed normal pituitary function, although his serum IgG4 level was high. The patient underwent a transsphenoidal biopsy of the pituitary gland, and the pathological tissues were consistent with IgG4-related hypophysitis. Oral prednisolone therapy was started, and after 6 months, his serum IgG4 level decreased and visual field improved. Conclusion: We described the first case of IgG4-related hypophysitis without pituitary insufficiency. However, further case collection is needed to characterize the pathophysiology of IgG4-related hypophysitis.
ISSN:	0021-972X 1945-7197
DOI:	10.1210/jc.2013-1088