Improved axonal regeneration after spinal cord injury in mice with conditional deletion of ephrin B2 under the GFAP promoter

Highlights • Conditional deletion of ephrin B2 resulted in decreased gliosis over controls. • Ephrin B2 on astrocytes was inhibitory to neurite outgrowth in an in-vitro assay. • Ephrin B2 knockout mice exhibited improved regeneration of injured corticospinal tract axons. • Ephrin B2 deletion resulte...

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Veröffentlicht in:	Neuroscience 2013-06, Vol.241, p.89-99
Hauptverfasser:	Ren, Z, Chen, X, Yang, J, Kress, B.T, Tong, J, Liu, H, Takano, T, Zhao, Y, Nedergaard, M
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Astrocytes - metabolism astrocytic gliosis axonal guidance molecules axonal regeneration Axons - physiology Biological and medical sciences Cells, Cultured Coculture Techniques Disease Models, Animal ephrin B2 Ephrin-B2 - metabolism Fundamental and applied biological sciences. Psychology Glial Fibrillary Acidic Protein - genetics Immunohistochemistry Mice Mice, Knockout Nerve Regeneration - physiology Neurology Promoter Regions, Genetic Real-Time Polymerase Chain Reaction Reverse Transcriptase Polymerase Chain Reaction Spinal Cord Injuries - metabolism spinal cord injury Transfection Vertebrates: nervous system and sense organs
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Zusammenfassung:	Highlights • Conditional deletion of ephrin B2 resulted in decreased gliosis over controls. • Ephrin B2 on astrocytes was inhibitory to neurite outgrowth in an in-vitro assay. • Ephrin B2 knockout mice exhibited improved regeneration of injured corticospinal tract axons. • Ephrin B2 deletion resulted in improved functional recovery over wild-type controls.
ISSN:	0306-4522 1873-7544
DOI:	10.1016/j.neuroscience.2013.03.010