Scleral Necrosis after Plaque Radiotherapy of Uveal Melanoma: A Case-Control Study

Purpose To identify risk factors and outcome of scleral necrosis after plaque radiotherapy of uveal melanoma. Design Case-control study. Participants A total of 73 cases with scleral necrosis and 73 controls without necrosis after plaque radiotherapy. Controls were matched for anteroposterior tumor...

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Veröffentlicht in:	Ophthalmology (Rochester, Minn.) Minn.), 2013-05, Vol.120 (5), p.1004-1011
Hauptverfasser:	Kaliki, Swathi, MD, Shields, Carol L., MD, Rojanaporn, Duangnate, MD, Badal, Josep, MD, Devisetty, Laxmi, MD, Emrich, Jacqueline, PhD, Komarnicky, Lydia, MD, Shields, Jerry A., MD
Format:	Artikel
Sprache:	eng
Schlagworte:	Adolescent Adult Aged Aged, 80 and over Brachytherapy - adverse effects Case-Control Studies Female Humans Male Melanoma - radiotherapy Middle Aged Necrosis - pathology Ophthalmology Radiation Injuries - pathology Retrospective Studies Risk Factors Sclera - pathology Sclera - radiation effects Uveal Neoplasms - radiotherapy Young Adult
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Zusammenfassung:	Purpose To identify risk factors and outcome of scleral necrosis after plaque radiotherapy of uveal melanoma. Design Case-control study. Participants A total of 73 cases with scleral necrosis and 73 controls without necrosis after plaque radiotherapy. Controls were matched for anteroposterior tumor epicenter and follow-up duration. Intervention Plaque radiotherapy with iodine-125, cobalt-60, iridium-192, or ruthenium-106. Main Outcome Measures Scleral necrosis. Results Of 5057 patients treated with plaque radiotherapy for uveal melanoma, 73 (1%) developed radiotherapy-induced scleral necrosis. Scleral necrosis occurred in
ISSN:	0161-6420 1549-4713
DOI:	10.1016/j.ophtha.2012.10.021