Mild Metal-Free Sequential Dual Oxidative Amination of C(sp3)–H bonds: Efficient Synthesis of Imidazo[1,5‑a]pyridines

Mild Metal-Free Sequential Dual Oxidative Amination of C(sp3)–H bonds: Efficient Synthesis of Imidazo[1,5‑a]pyridines

A metal-free sequential dual oxidative amination of C(sp3)–H bonds under ambient conditions was the first developed, affording imidazo[1,5-a]pyridines in good to excellent yields. The reaction was involved in two oxidative C–N couplings and one oxidative dehydrogenation process with six hydrogen ato...

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Veröffentlicht in:Organic letters 2013-05, Vol.15 (9), p.2274-2277
Hauptverfasser: Yan, Yizhe, Zhang, Yonghui, Zha, Zhenggen, Wang, Zhiyong
Format: Artikel
Sprache:eng
Schlagworte:
Amination
Hydrogen Bonding
Imidazoles - chemical synthesis
Imidazoles - chemistry
Molecular Structure
Oxidation-Reduction
Pyridines - chemical synthesis
Pyridines - chemistry
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Zusammenfassung:A metal-free sequential dual oxidative amination of C(sp3)–H bonds under ambient conditions was the first developed, affording imidazo[1,5-a]pyridines in good to excellent yields. The reaction was involved in two oxidative C–N couplings and one oxidative dehydrogenation process with six hydrogen atoms removed.
ISSN:1523-7060
1523-7052
DOI:10.1021/ol4008487