Local and systemic immune responses in pigs intramuscularly injected with an inactivated Mycoplasma hyopneumoniae vaccine

Highlights ► M. hyopneumoniae specific IgG, IgM and IgA were detected in BAL fluid. ► Higher IL-12 secreting cells were observed in the lung of vaccinated group. ► The number of IL-10 secreting cells from BLN was higher in the vaccinated group. ► Vaccine induced both systemic and mucosal cellular an...

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Veröffentlicht in:	Vaccine 2013-02, Vol.31 (9), p.1305-1311
Hauptverfasser:	Marchioro, Silvana Beutinger, Maes, Dominiek, Flahou, Bram, Pasmans, Frank, Del Pozo Sacristán, Rubén, Vranckx, Katleen, Melkebeek, Vesna, Cox, Eric, Wuyts, Niels, Haesebrouck, Freddy
Format:	Artikel
Sprache:	eng
Schlagworte:	Allergy and Immunology Animals antibodies Antibodies, Bacterial - analysis Antibodies, Bacterial - blood Applied microbiology Bacterial Vaccines - administration & dosage Bacterial Vaccines - immunology Bacteriology Biological and medical sciences Blood - immunology blood serum Bronchoalveolar Lavage Fluid - immunology Cytokines - secretion Enzootic pneumonia Enzyme-Linked Immunosorbent Assay Enzyme-Linked Immunospot Assay Flow Cytometry Fundamental and applied biological sciences. Psychology humoral immunity Immune response immunoglobulin A Immunoglobulin A - analysis Immunoglobulin A - blood immunoglobulin G Immunoglobulin G - analysis Immunoglobulin G - blood immunoglobulin M Immunoglobulin M - analysis Immunoglobulin M - blood Injections, Intramuscular interleukin-10 interleukin-12 intramuscular injection Leukocytes, Mononuclear - immunology lungs lymph nodes Microbiology Miscellaneous Mycoplasma Mycoplasma hyopneumoniae Mycoplasma hyopneumoniae - immunology Pneumonia of Swine, Mycoplasmal - immunology Pneumonia of Swine, Mycoplasmal - prevention & control sodium chloride spleen Swine T-lymphocytes Vaccine vaccines Vaccines, antisera, therapeutical immunoglobulins and monoclonal antibodies (general aspects) Vaccines, Inactivated - administration & dosage Vaccines, Inactivated - immunology
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Zusammenfassung:	Highlights ► M. hyopneumoniae specific IgG, IgM and IgA were detected in BAL fluid. ► Higher IL-12 secreting cells were observed in the lung of vaccinated group. ► The number of IL-10 secreting cells from BLN was higher in the vaccinated group. ► Vaccine induced both systemic and mucosal cellular and humoral immune responses.
ISSN:	0264-410X 1873-2518
DOI:	10.1016/j.vaccine.2012.12.068