DNA ploidy: a prognostic factor of response to chemotherapy and survival in metastatic gastric adenocarcinoma

Metastatic gastric adenocarcinoma confers a dismal prognosis. Several prognostic factors are needed to distinguish patients that will benefit from chemotherapy. In this setting, the prognostic impact of DNA ploidy is still unclear. The records of 61 patients with metastatic gastric adenocarcinoma we...

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Veröffentlicht in:	Anticancer research 2013-03, Vol.33 (3), p.1209-1214
Hauptverfasser:	Syrios, John, Kechagias, Georgios, Agrogiannis, George, Xynos, Ioannis D, Kavantzas, Nikolaos, Lazaris, Andreas C, Amptoulach, Suzanna, Mourati, Aikaterini, Sougioultzis, Stavros, Patsouris, Efstratios S, Tsavaris, Nikolas
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenocarcinoma - drug therapy Adenocarcinoma - genetics Adenocarcinoma - mortality Adenocarcinoma - pathology DNA, Neoplasm - analysis Female Humans Male Middle Aged Neoplasm Metastasis Ploidies Prognosis Stomach Neoplasms - drug therapy Stomach Neoplasms - genetics Stomach Neoplasms - mortality Stomach Neoplasms - pathology
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Zusammenfassung:	Metastatic gastric adenocarcinoma confers a dismal prognosis. Several prognostic factors are needed to distinguish patients that will benefit from chemotherapy. In this setting, the prognostic impact of DNA ploidy is still unclear. The records of 61 patients with metastatic gastric adenocarcinoma were retrospectively reviewed. Response to chemotherapy and overall survival (OS) were assessed and correlated to tumour DNA ploidy index, which was calculated by cytometric image analysis. The median value of DNA ploidy index was 2.3. Patients with a low index responded better to chemotherapy than those with a higher index (p
ISSN:	0250-7005 1791-7530