Do gamma delta T Cells Predict Osteonecrosis of the Jaw?

A large body of evidence has established that T cells and cytokine mediators originating from the immune system potently impact bone turnover in both physiologic and pathologic conditions. Indeed, osteoclasts derive from precursors that circulate within the immune compartment; however, new revelations continue to emerge attesting to the depth of integration of the skeletal and immune systems, and the consequences of the immuno-skeletal interface for bone metabolism.