Intratumoral injection of attenuated Salmonella vaccine can induce tumor microenvironmental shift from immune suppressive to immunogenic

Intratumoral injection of attenuated Salmonella vaccine can induce tumor microenvironmental shift from immune suppressive to immunogenic

Highlights ► Attenuated Salmonella vaccine (RASV) significantly inhibited tumor growth. ► RASV significantly increased TNF-α-secreting CD11b+ Gr-1+ myeloid cells. ► RASV significantly reduced CD4+ CD25+ Foxp3+ Tregs. ► RASV can induce a tumor microenvironmental shift from suppressive to immunogenic....

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Veröffentlicht in:Vaccine 2013-02, Vol.31 (10), p.1377-1384
Hauptverfasser: Hong, Eun-Hye, Chang, Sun-Young, Lee, Bo-Ra, Pyun, A.-Rim, Kim, Ji-Won, Kweon, Mi-Na, Ko, Hyun-Jeong
Format: Artikel
Sprache:eng
Schlagworte:
Allergy and Immunology
Animals
antineoplastic agents
Applied microbiology
Bacteriology
Biological and medical sciences
CTL
cytotoxic T-lymphocytes
Disease Models, Animal
Flow Cytometry
Fundamental and applied biological sciences. Psychology
Humans
Immunologic Factors - administration & dosage
Injections - methods
MDSC
Medical sciences
Mice
Mice, Inbred BALB C
Mice, Inbred C57BL
Microbiology
Miscellaneous
neoplasms
Neoplasms - immunology
Neoplasms - pathology
neutrophils
Salmonella
Salmonella enterica
Salmonella Typhimurium
Salmonella typhimurium - immunology
Salmonella Vaccines - administration & dosage
Salmonella Vaccines - immunology
T-Lymphocyte Subsets - chemistry
T-Lymphocyte Subsets - immunology
Treg
Tumor
Tumors
Vaccination - methods
vaccines
Vaccines, antisera, therapeutical immunoglobulins and monoclonal antibodies (general aspects)
Vaccines, Attenuated - administration & dosage
Vaccines, Attenuated - immunology
Vaccines, Synthetic - administration & dosage
Vaccines, Synthetic - immunology
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Beschreibung
Zusammenfassung:Highlights ► Attenuated Salmonella vaccine (RASV) significantly inhibited tumor growth. ► RASV significantly increased TNF-α-secreting CD11b+ Gr-1+ myeloid cells. ► RASV significantly reduced CD4+ CD25+ Foxp3+ Tregs. ► RASV can induce a tumor microenvironmental shift from suppressive to immunogenic.
ISSN:0264-410X
1873-2518
DOI:10.1016/j.vaccine.2013.01.006