HI responses induced by seasonal influenza vaccination are associated with clinical protection and with seroprotection against non-homologous strains

HI responses induced by seasonal influenza vaccination are associated with clinical protection and with seroprotection against non-homologous strains

Highlights ► We examine homologous and cross-specific HI responses after influenza vaccination in 2006/2007. ► Homologous HI titers before and after vaccination correlate with laboratory confirmed influenza. ► Vaccination will induce cross-specific HI titers ≥40 against H1N1pdm09 and drifted seasona...

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Veröffentlicht in:Vaccine 2012-07, Vol.30 (35), p.5262-5269
Hauptverfasser: Luytjes, Willem, Enouf, Vincent, Schipper, Maarten, Gijzen, Karlijn, Liu, Wai Ming, van der Lubben, Mariken, Meijer, Adam, van der Werf, Sylvie, Soethout, Ernst C
Format: Artikel
Sprache:eng
Schlagworte:
Adolescent
Adult
Age
Allergy and Immunology
Antibodies, Viral - blood
Binding sites
Clinical study
Cohort Studies
Cross Protection
Cross-specific immunity
Female
Follow-Up Studies
hemagglutination
Hemagglutination inhibition
Hemagglutination Inhibition Tests
Hemophilia
Humans
Immunity, Humoral
Infections
Influenza
Influenza A virus
Influenza A Virus, H1N1 Subtype - immunology
Influenza A Virus, H1N1 Subtype - isolation & purification
Influenza A Virus, H1N1 Subtype - pathogenicity
Influenza Vaccines - administration & dosage
Influenza Vaccines - immunology
Influenza virus
Influenza, Human - immunology
Influenza, Human - prevention & control
Logistic Models
Male
Middle Aged
Older people
pandemic
Pandemics
Studies
Swine flu
Vaccination
Vaccines
Young Adult
young adults
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Beschreibung
Zusammenfassung:Highlights ► We examine homologous and cross-specific HI responses after influenza vaccination in 2006/2007. ► Homologous HI titers before and after vaccination correlate with laboratory confirmed influenza. ► Vaccination will induce cross-specific HI titers ≥40 against H1N1pdm09 and drifted seasonal H1N1. ► We find no indications that original antigenic sin may affect cross-specific HI titers. ► Between 20 and 60 years, cross-specific HI titers ≥40 against H1N1pdm09 are inversely correlated with age.
ISSN:0264-410X
1873-2518
DOI:10.1016/j.vaccine.2012.05.060