Changes in the composition of the pneumococcal population and in IPD incidence in The Netherlands after the implementation of the 7-valent pneumococcal conjugate vaccine

Abstract The implementation of nationwide pneumococcal vaccination may lead to alterations in the pneumococcal population due to selective pressure induced by the vaccine. To monitor such changes, pneumococcal isolates causing invasive pneumococcal disease (IPD) before (2004–2005, n = 1154) and afte...

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Veröffentlicht in:	Vaccine 2012-12, Vol.30 (52), p.7644-7651
Hauptverfasser:	Elberse, Karin E.M, van der Heide, Han G.J, Witteveen, Sandra, van de Pol, Ingrid, Schot, Corrie S, van der Ende, Arie, Berbers, Guy A.M, Schouls, Leo M
Format:	Artikel
Sprache:	eng
Schlagworte:	Adolescent Adult Age Aged Aged, 80 and over Allergy and Immunology Bacterial Capsules - genetics Child Child, Preschool children Female Genes genetic background Heptavalent Pneumococcal Conjugate Vaccine Herd immunity herds Humans immunity Immunization Incidence Infant Infant, Newborn IPD incidence Laboratories loci Male Meningitis Meningitis, Pneumococcal - epidemiology Meningitis, Pneumococcal - microbiology Middle Aged Minisatellite Repeats MLVA Molecular Epidemiology Molecular typing Multilocus Sequence Typing Netherlands - epidemiology patients Pneumococcal conjugate vaccine Pneumococcal population Pneumococcal Vaccines - administration & dosage Pneumococcal Vaccines - immunology Pneumococcus Pneumonia serotypes Streptococcus pneumoniae Streptococcus pneumoniae - classification Streptococcus pneumoniae - genetics Streptococcus pneumoniae - isolation & purification Temporal changes vaccination Vaccines Young Adult
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Zusammenfassung:	Abstract The implementation of nationwide pneumococcal vaccination may lead to alterations in the pneumococcal population due to selective pressure induced by the vaccine. To monitor such changes, pneumococcal isolates causing invasive pneumococcal disease (IPD) before (2004–2005, n = 1154) and after (2008–2009, n = 1190) the implementation of the 7-valent pneumococcal vaccine (PCV7) in 2006 in the national immunization program (NIP) of The Netherlands were characterized by molecular typing using multiple-locus variable number tandem repeat analysis (MLVA) and capsular sequence typing (CST). The IPD incidence after the implementation of PCV7 in children
ISSN:	0264-410X 1873-2518
DOI:	10.1016/j.vaccine.2012.04.021