History of the restoration of adenovirus type 4 and type 7 vaccine, live oral (Adenovirus Vaccine) in the context of the Department of Defense acquisition system

History of the restoration of adenovirus type 4 and type 7 vaccine, live oral (Adenovirus Vaccine) in the context of the Department of Defense acquisition system

Highlights ► FDA licensed vaccine prevented adenovirus disease in military trainees until 1999. ► Without vaccine to protect trainees, disease, mainly due to serotype 4, returned. ► DoD medical leadership became convinced of the need to restore the vaccine. ► Following vaccine deployment, adenovirus...

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Veröffentlicht in:Vaccine 2013-03, Vol.31 (12), p.1623-1632
Hauptverfasser: Hoke, Charles H, Snyder, Clifford E
Format: Artikel
Sprache:eng
Schlagworte:
Acquisition
Adenoviridae
Adenovirus
Adenovirus Infections, Human - epidemiology
Adenovirus Infections, Human - prevention & control
Adenovirus Vaccines - administration & dosage
Adenovirus Vaccines - history
Adenoviruses, Human - isolation & purification
Allergy and Immunology
Applied microbiology
Biological and medical sciences
Clinical Trials as Topic
Defense contracts
Fundamental and applied biological sciences. Psychology
History, 20th Century
History, 21st Century
human resources
Humans
Immunization
Immunization Programs - history
Immunization Programs - organization & administration
influenza
Leadership
Mandatory Programs
Manufacturing
Microbiology
Military Personnel
Miscellaneous
morbidity
mortality
Neisseria meningitidis
pandemic
pathogens
Prevention
Respiratory diseases
serotypes
Sustainment
United States - epidemiology
United States Department of Defense
US military
Vaccine
Vaccines
Vaccines, antisera, therapeutical immunoglobulins and monoclonal antibodies (general aspects)
Virology
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Beschreibung
Zusammenfassung:Highlights ► FDA licensed vaccine prevented adenovirus disease in military trainees until 1999. ► Without vaccine to protect trainees, disease, mainly due to serotype 4, returned. ► DoD medical leadership became convinced of the need to restore the vaccine. ► Following vaccine deployment, adenovirus type 4 transmission was interrupted. ► Sustainment of the vaccine in the future remains a formidable challenge.
ISSN:0264-410X
1873-2518
DOI:10.1016/j.vaccine.2012.12.029