Identification of novel HLA-A0201-restricted cytotoxic T lymphocyte epitopes from Zinc Transporter 8
Highlights ► We predicted and identified HLA-A*0201-restricted CTL epitope from ZnT8. ► We utilized it to immunize HLA-A2.1/Kb transgenic (Tg) mice. ► The peptides could elicit specific CTLs in vitro , and induce diabetes in mice. ► The peptides could have therapeutic potential in preventing of T1D....
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| Veröffentlicht in: | Vaccine 2013-03, Vol.31 (12), p.1610-1615 |
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| container_end_page | 1615 |
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| container_issue | 12 |
| container_start_page | 1610 |
| container_title | Vaccine |
| container_volume | 31 |
| creator | Li, Shufa Li, Haiying Chen, Bing Lu, Debin Deng, Wuquan Jiang, Youzhao Zhou, Zhongqi Yang, Zhao |
| description | Highlights ► We predicted and identified HLA-A*0201-restricted CTL epitope from ZnT8. ► We utilized it to immunize HLA-A2.1/Kb transgenic (Tg) mice. ► The peptides could elicit specific CTLs in vitro , and induce diabetes in mice. ► The peptides could have therapeutic potential in preventing of T1D. |
| doi_str_mv | 10.1016/j.vaccine.2012.12.008 |
| format | Article |
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| fulltext | fulltext |
| identifier | ISSN: 0264-410X |
| ispartof | Vaccine, 2013-03, Vol.31 (12), p.1610-1615 |
| issn | 0264-410X 1873-2518 |
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| source | ScienceDirect Journals (5 years ago - present); ProQuest Central UK/Ireland |
| subjects | Algorithms Allergy and Immunology Applied microbiology Biological and medical sciences Cytotoxic T lymphocyte Cytotoxicity Diabetes Epitopes Fundamental and applied biological sciences. Psychology HLA-A0201 Immunization Lymphocytes Microbiology Peptides Rodents Social change Vaccines, antisera, therapeutical immunoglobulins and monoclonal antibodies (general aspects) Zinc Transporter 8 |
| title | Identification of novel HLA-A0201-restricted cytotoxic T lymphocyte epitopes from Zinc Transporter 8 |
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