Identification of novel HLA-A0201-restricted cytotoxic T lymphocyte epitopes from Zinc Transporter 8

Highlights ► We predicted and identified HLA-A*0201-restricted CTL epitope from ZnT8. ► We utilized it to immunize HLA-A2.1/Kb transgenic (Tg) mice. ► The peptides could elicit specific CTLs in vitro , and induce diabetes in mice. ► The peptides could have therapeutic potential in preventing of T1D....

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Veröffentlicht in:	Vaccine 2013-03, Vol.31 (12), p.1610-1615
Hauptverfasser:	Li, Shufa, Li, Haiying, Chen, Bing, Lu, Debin, Deng, Wuquan, Jiang, Youzhao, Zhou, Zhongqi, Yang, Zhao
Format:	Artikel
Sprache:	eng
Schlagworte:	Algorithms Allergy and Immunology Applied microbiology Biological and medical sciences Cytotoxic T lymphocyte Cytotoxicity Diabetes Epitopes Fundamental and applied biological sciences. Psychology HLA-A0201 Immunization Lymphocytes Microbiology Peptides Rodents Social change Vaccines, antisera, therapeutical immunoglobulins and monoclonal antibodies (general aspects) Zinc Transporter 8
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Beschreibung
Zusammenfassung:	Highlights ► We predicted and identified HLA-A*0201-restricted CTL epitope from ZnT8. ► We utilized it to immunize HLA-A2.1/Kb transgenic (Tg) mice. ► The peptides could elicit specific CTLs in vitro , and induce diabetes in mice. ► The peptides could have therapeutic potential in preventing of T1D.
ISSN:	0264-410X 1873-2518
DOI:	10.1016/j.vaccine.2012.12.008