Rabies virus vaccines: Is there a need for a pan-lyssavirus vaccine?
Highlights ► All lyssaviruses can cause fatal encephalitic disease. ► Rabies vaccines protect against phylogroup I lyssaviruses but not against phylogroup II viruses. ► Here we review lyssavirus vaccinology and focus on the antigenicity of the glycoprotein. ► The discovery of divergent lyssaviruses...
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Veröffentlicht in: | Vaccine 2012-12, Vol.30 (52), p.7447-7454 |
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creator | Evans, Jennifer S Horton, Daniel L Easton, Andrew J Fooks, Anthony R Banyard, Ashley C |
description | Highlights ► All lyssaviruses can cause fatal encephalitic disease. ► Rabies vaccines protect against phylogroup I lyssaviruses but not against phylogroup II viruses. ► Here we review lyssavirus vaccinology and focus on the antigenicity of the glycoprotein. ► The discovery of divergent lyssaviruses suggests a need for novel pan-lyssavirus vaccines. |
doi_str_mv | 10.1016/j.vaccine.2012.10.015 |
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subjects | Allergy and Immunology Animals antigenic variation Bats death Fatalities Genetic Variation Glycoprotein glycoproteins Humans Lyssavirus Lyssaviruses pathogens Protection Rabies Rabies - prevention & control Rabies - veterinary Rabies - virology Rabies Vaccines - immunology Rabies virus Rabies virus - classification Rabies virus - genetics Rabies virus - immunology risk Vaccines viruses |
title | Rabies virus vaccines: Is there a need for a pan-lyssavirus vaccine? |
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