Rabies virus vaccines: Is there a need for a pan-lyssavirus vaccine?

Highlights ► All lyssaviruses can cause fatal encephalitic disease. ► Rabies vaccines protect against phylogroup I lyssaviruses but not against phylogroup II viruses. ► Here we review lyssavirus vaccinology and focus on the antigenicity of the glycoprotein. ► The discovery of divergent lyssaviruses...

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Veröffentlicht in:	Vaccine 2012-12, Vol.30 (52), p.7447-7454
Hauptverfasser:	Evans, Jennifer S, Horton, Daniel L, Easton, Andrew J, Fooks, Anthony R, Banyard, Ashley C
Format:	Artikel
Sprache:	eng
Schlagworte:	Allergy and Immunology Animals antigenic variation Bats death Fatalities Genetic Variation Glycoprotein glycoproteins Humans Lyssavirus Lyssaviruses pathogens Protection Rabies Rabies - prevention & control Rabies - veterinary Rabies - virology Rabies Vaccines - immunology Rabies virus Rabies virus - classification Rabies virus - genetics Rabies virus - immunology risk Vaccines viruses
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Beschreibung
Zusammenfassung:	Highlights ► All lyssaviruses can cause fatal encephalitic disease. ► Rabies vaccines protect against phylogroup I lyssaviruses but not against phylogroup II viruses. ► Here we review lyssavirus vaccinology and focus on the antigenicity of the glycoprotein. ► The discovery of divergent lyssaviruses suggests a need for novel pan-lyssavirus vaccines.
ISSN:	0264-410X 1873-2518
DOI:	10.1016/j.vaccine.2012.10.015