Atypical Leydig Cell Hyperplasia in Adult Rats with Low T and High LH Induced by Prenatal Di(n-butyl) Phthalate Exposure

The present study describes atypical Leydig cell (LC) hyperplasia in 20-week-old Sprague-Dawley rats with low testosterone and high luteinizing hormone levels after prenatal administration of 100 mg/kg/day di(n-butyl) phthalate on days 12 to 21 postconception. Light microscopy revealed LC hyperplasi...

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Veröffentlicht in:	Toxicologic pathology 2013-04, Vol.41 (3), p.480-486
Hauptverfasser:	Wakui, Shin, Takahashi, Hiroyuki, Mutou, Tomoko, Shirai, Masaru, Jutabha, Promsuk, Anzai, Naohiko, Wempe, Michael F., Kansaku, Norio, Hano, Hiroshi, Inomata, Tomo, Endou, Hitoshi
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biological and medical sciences Dibutyl Phthalate - toxicity Female Histocytochemistry Hyperplasia - chemically induced Hyperplasia - pathology Leydig Cells - drug effects Leydig Cells - pathology Luteinizing Hormone - blood Male Medical sciences Pregnancy Prenatal Exposure Delayed Effects - chemically induced Prenatal Exposure Delayed Effects - pathology Rats Rats, Sprague-Dawley Testis - chemistry Testis - drug effects Testis - pathology Testosterone - metabolism Toxicology
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