Atypical Leydig Cell Hyperplasia in Adult Rats with Low T and High LH Induced by Prenatal Di(n-butyl) Phthalate Exposure

The present study describes atypical Leydig cell (LC) hyperplasia in 20-week-old Sprague-Dawley rats with low testosterone and high luteinizing hormone levels after prenatal administration of 100 mg/kg/day di(n-butyl) phthalate on days 12 to 21 postconception. Light microscopy revealed LC hyperplasi...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Toxicologic pathology 2013-04, Vol.41 (3), p.480-486
Hauptverfasser:	Wakui, Shin, Takahashi, Hiroyuki, Mutou, Tomoko, Shirai, Masaru, Jutabha, Promsuk, Anzai, Naohiko, Wempe, Michael F., Kansaku, Norio, Hano, Hiroshi, Inomata, Tomo, Endou, Hitoshi
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biological and medical sciences Dibutyl Phthalate - toxicity Female Histocytochemistry Hyperplasia - chemically induced Hyperplasia - pathology Leydig Cells - drug effects Leydig Cells - pathology Luteinizing Hormone - blood Male Medical sciences Pregnancy Prenatal Exposure Delayed Effects - chemically induced Prenatal Exposure Delayed Effects - pathology Rats Rats, Sprague-Dawley Testis - chemistry Testis - drug effects Testis - pathology Testosterone - metabolism Toxicology
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Beschreibung
Zusammenfassung:	The present study describes atypical Leydig cell (LC) hyperplasia in 20-week-old Sprague-Dawley rats with low testosterone and high luteinizing hormone levels after prenatal administration of 100 mg/kg/day di(n-butyl) phthalate on days 12 to 21 postconception. Light microscopy revealed LC hyperplasia surrounded by severely degenerated seminiferous tubules. Aggregated LCs had large ovoid nuclei with nucleoli and abundant eosinophilic cytoplasm. Immunohistochemical analysis showed expression of proliferating cell nuclear antigen and vimentin in many hyperplastic LCs. Electron microscopy revealed atypical nuclei, abundant free ribosomes, stripped rough endoplasmic reticulum, intermediate-size filaments, elongated cytoplasmic filopodia, atypical tight junctions, and cilia formations, but smooth endoplasmic reticulum was scarcely observed.
ISSN:	0192-6233 1533-1601
DOI:	10.1177/0192623312457272