Copper-catalyzed aerobic oxidative synthesis of aryl nitriles from benzylic alcohols and aqueous ammonia

Copper-catalyzed aerobic oxidative synthesis of aryl nitriles from benzylic alcohols and aqueous ammonia

Copper-catalyzed direct conversion of benzylic alcohols to aryl nitriles was realized using NH3(aq.) as the nitrogen source, O2 as the oxidant and TEMPO as the co-catalyst. Furthermore, copper-catalyzed one-pot synthesis of primary aryl amides from alcohols was also achieved.

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Veröffentlicht in:Organic & biomolecular chemistry 2013-05, Vol.11 (20), p.3349-3354
Hauptverfasser: Tao, Chuanzhou, Liu, Feng, Zhu, Youmin, Liu, Weiwei, Cao, Zhiling
Format: Artikel
Sprache:eng
Schlagworte:
Ammonia - chemistry
Benzyl Alcohols - chemistry
Catalysis
Copper - chemistry
Molecular Structure
Nitrates - chemistry
Nitriles - chemical synthesis
Nitriles - chemistry
Oxidation-Reduction
Water - chemistry
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Zusammenfassung:Copper-catalyzed direct conversion of benzylic alcohols to aryl nitriles was realized using NH3(aq.) as the nitrogen source, O2 as the oxidant and TEMPO as the co-catalyst. Furthermore, copper-catalyzed one-pot synthesis of primary aryl amides from alcohols was also achieved.
ISSN:1477-0520
1477-0539
DOI:10.1039/c3ob00002h