The impact of placental malaria on neurodevelopment of exposed infants: a role for the complement system?

Highlights ► Complement activation is associated with placental malaria (PM) and fetal growth restriction. ► Complement plays a role in both neurodevelopment and neurological disease. ► PM may disrupt fetal neurodevelopment via excessive complement activation. ► PM may cause neurocognitive impairmen...

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Veröffentlicht in:	Trends in parasitology 2013-05, Vol.29 (5), p.213-219
Hauptverfasser:	McDonald, Chloe R, Elphinstone, Robyn E, Kain, Kevin C
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Brain - embryology Brain - growth & development central nervous system development cognitive development Complement Activation complement cascade Complement System Proteins - immunology Female Gastroenterology and Hepatology Humans in utero environment Infant Infectious Disease malaria Malaria - complications Malaria - parasitology Malaria - physiopathology maternal infection Neurodegenerative Diseases - etiology Neurodegenerative Diseases - parasitology placenta Placenta - parasitology Plasmodium - physiology Pregnancy Pregnancy Complications, Parasitic - parasitology Pregnancy Complications, Parasitic - physiopathology
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Zusammenfassung:	Highlights ► Complement activation is associated with placental malaria (PM) and fetal growth restriction. ► Complement plays a role in both neurodevelopment and neurological disease. ► PM may disrupt fetal neurodevelopment via excessive complement activation. ► PM may cause neurocognitive impairment of infants exposed to malaria in utero.
ISSN:	1471-4922 1471-5007
DOI:	10.1016/j.pt.2013.03.005