A Pt(II)-Dip complex stabilizes parallel c-myc G-quadruplex
A new G-quadruplex (GQ) stabilizer, [Pt(Dip)2](PF6)2 (Dip: 4,7-diphenyl-1,10-phenanthroline), is prepared by the microwave irradiation method. The complex can highly stabilize G-quadruplex, but has negligible interactions with duplex DNA. Aromatic anchors on the polypyridyl ligands bestow the stabil...
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| Veröffentlicht in: | Chemical communications (Cambridge, England) England), 2013-05, Vol.49 (42), p.4758-4760 |
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| container_issue | 42 |
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| container_title | Chemical communications (Cambridge, England) |
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| creator | Wang, Jintao Lu, Kaihui Xuan, Shuguang Toh, Zaozhen Zhang, Dawei Shao, Fangwei |
| description | A new G-quadruplex (GQ) stabilizer, [Pt(Dip)2](PF6)2 (Dip: 4,7-diphenyl-1,10-phenanthroline), is prepared by the microwave irradiation method. The complex can highly stabilize G-quadruplex, but has negligible interactions with duplex DNA. Aromatic anchors on the polypyridyl ligands bestow the stabilizer with a high binding preference towards parallel GQ. |
| doi_str_mv | 10.1039/c3cc40868j |
| format | Article |
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Aromatic anchors on the polypyridyl ligands bestow the stabilizer with a high binding preference towards parallel GQ.</description><subject>Cell Line, Tumor</subject><subject>Cell Survival - drug effects</subject><subject>G-Quadruplexes</subject><subject>Humans</subject><subject>Phenanthrolines - chemistry</subject><subject>Phenanthrolines - pharmacology</subject><subject>Platinum - chemistry</subject><subject>Platinum - pharmacology</subject><subject>Proto-Oncogene Proteins c-myc</subject><issn>1359-7345</issn><issn>1364-548X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2013</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpFkE1Lw0AQhhdRbK1e_AGSYxVWd7PfeCpVa6Cghx68he1mAikbk-4mYP31prTqXN45PLwzPAhdU3JPCTMPjjnHiZZ6c4LGlEmOBdcfp_tdGKwYFyN0EeOGDEOFPkejlAktidJj9DhL3rtplt3ip6pNXFO3Hr6S2Nl15atviElrg_UefOJwvXPJAm97W4R-j12is9L6CFfHnKDVy_Nq_oqXb4tsPltix1LWYSN1KqgzoBU46goOtAQ-XDdOSbUWJQUBmpaMCmsKmRKj7PAdZTbVzig2QdNDbRuabQ-xy-sqOvDefkLTx5wyrrhkRqUDendAXWhiDFDmbahqG3Y5JfneVf7vaoBvjr39uobiD_2Vw34APChiZQ</recordid><startdate>20130525</startdate><enddate>20130525</enddate><creator>Wang, Jintao</creator><creator>Lu, Kaihui</creator><creator>Xuan, Shuguang</creator><creator>Toh, Zaozhen</creator><creator>Zhang, Dawei</creator><creator>Shao, Fangwei</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20130525</creationdate><title>A Pt(II)-Dip complex stabilizes parallel c-myc G-quadruplex</title><author>Wang, Jintao ; Lu, Kaihui ; Xuan, Shuguang ; Toh, Zaozhen ; Zhang, Dawei ; Shao, Fangwei</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c323t-968251c9e87ec1cd4e1fe40789c767b5f1e5e81f315a9d62097a86013a28c973</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2013</creationdate><topic>Cell Line, Tumor</topic><topic>Cell Survival - drug effects</topic><topic>G-Quadruplexes</topic><topic>Humans</topic><topic>Phenanthrolines - chemistry</topic><topic>Phenanthrolines - pharmacology</topic><topic>Platinum - chemistry</topic><topic>Platinum - pharmacology</topic><topic>Proto-Oncogene Proteins c-myc</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Wang, Jintao</creatorcontrib><creatorcontrib>Lu, Kaihui</creatorcontrib><creatorcontrib>Xuan, Shuguang</creatorcontrib><creatorcontrib>Toh, Zaozhen</creatorcontrib><creatorcontrib>Zhang, Dawei</creatorcontrib><creatorcontrib>Shao, Fangwei</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Chemical communications (Cambridge, England)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Wang, Jintao</au><au>Lu, Kaihui</au><au>Xuan, Shuguang</au><au>Toh, Zaozhen</au><au>Zhang, Dawei</au><au>Shao, Fangwei</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>A Pt(II)-Dip complex stabilizes parallel c-myc G-quadruplex</atitle><jtitle>Chemical communications (Cambridge, England)</jtitle><addtitle>Chem Commun (Camb)</addtitle><date>2013-05-25</date><risdate>2013</risdate><volume>49</volume><issue>42</issue><spage>4758</spage><epage>4760</epage><pages>4758-4760</pages><issn>1359-7345</issn><eissn>1364-548X</eissn><abstract>A new G-quadruplex (GQ) stabilizer, [Pt(Dip)2](PF6)2 (Dip: 4,7-diphenyl-1,10-phenanthroline), is prepared by the microwave irradiation method. 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| ispartof | Chemical communications (Cambridge, England), 2013-05, Vol.49 (42), p.4758-4760 |
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| source | MEDLINE; Royal Society Of Chemistry Journals; Alma/SFX Local Collection |
| subjects | Cell Line, Tumor Cell Survival - drug effects G-Quadruplexes Humans Phenanthrolines - chemistry Phenanthrolines - pharmacology Platinum - chemistry Platinum - pharmacology Proto-Oncogene Proteins c-myc |
| title | A Pt(II)-Dip complex stabilizes parallel c-myc G-quadruplex |
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