A Pt(II)-Dip complex stabilizes parallel c-myc G-quadruplex

A Pt(II)-Dip complex stabilizes parallel c-myc G-quadruplex

A new G-quadruplex (GQ) stabilizer, [Pt(Dip)2](PF6)2 (Dip: 4,7-diphenyl-1,10-phenanthroline), is prepared by the microwave irradiation method. The complex can highly stabilize G-quadruplex, but has negligible interactions with duplex DNA. Aromatic anchors on the polypyridyl ligands bestow the stabil...

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Veröffentlicht in:Chemical communications (Cambridge, England) England), 2013-05, Vol.49 (42), p.4758-4760
Hauptverfasser: Wang, Jintao, Lu, Kaihui, Xuan, Shuguang, Toh, Zaozhen, Zhang, Dawei, Shao, Fangwei
Format: Artikel
Sprache:eng
Schlagworte:
Cell Line, Tumor
Cell Survival - drug effects
G-Quadruplexes
Humans
Phenanthrolines - chemistry
Phenanthrolines - pharmacology
Platinum - chemistry
Platinum - pharmacology
Proto-Oncogene Proteins c-myc
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Zusammenfassung:A new G-quadruplex (GQ) stabilizer, [Pt(Dip)2](PF6)2 (Dip: 4,7-diphenyl-1,10-phenanthroline), is prepared by the microwave irradiation method. The complex can highly stabilize G-quadruplex, but has negligible interactions with duplex DNA. Aromatic anchors on the polypyridyl ligands bestow the stabilizer with a high binding preference towards parallel GQ.
ISSN:1359-7345
1364-548X
DOI:10.1039/c3cc40868j