Insulin-degrading enzyme deficiency accelerates cerebrovascular amyloidosis in an animal model

Highlights ► TGF-β1 can reduce insulin degrading enzyme expression in mouse brain endothelial cell resulting in cerebrovascular amyloidosis.

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Bibliographische Detailangaben
Veröffentlicht in:	Brain, behavior, and immunity behavior, and immunity, 2013-05, Vol.30, p.143-149
Hauptverfasser:	Lifshitz, Veronica, Benromano, Tali, Weiss, Ronen, Blanga-Kanfi, Shani, Frenkel, Dan
Format:	Artikel
Sprache:	eng
Schlagworte:	Allergy and Immunology Alzheimer’s disease Amyloidosis - metabolism Amyloidosis - pathology Animals Astrocytes - metabolism Astrocytes - pathology Brain - metabolism Brain - pathology Cells, Cultured Cerebrovascular disease Cerebrovascular Disorders - metabolism Cerebrovascular Disorders - pathology Endothelial cells Endothelial Cells - metabolism Insulin-degrading enzyme Insulysin - deficiency Insulysin - metabolism Mice Mice, Transgenic Psychiatry Synaptophysin - metabolism TGF-β1 Transforming Growth Factor beta1 - genetics Transforming Growth Factor beta1 - metabolism
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Beschreibung
Zusammenfassung:	Highlights ► TGF-β1 can reduce insulin degrading enzyme expression in mouse brain endothelial cell resulting in cerebrovascular amyloidosis.
ISSN:	0889-1591 1090-2139
DOI:	10.1016/j.bbi.2012.12.003