In vivo antioxidant and biochemical evaluation of Sphenocentrum jollyanum leaf extract in P. berghei infected mice

Recent approach in treatment and drug development suggested that the control of oxidative stress in malarial infected patients may be an added advantage. In this study, effect of methanolic leaf extract of Sphenocentrum jollyanum pier (S. jollyanum) on liver damage, markers of oxidative stress and a...

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Veröffentlicht in:	Pakistan journal of pharmaceutical sciences 2013-05, Vol.26 (3), p.445-450
Hauptverfasser:	Olorunnisola, Olubukola Sinbad, Afolayan, Anthony Jide
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antimalarials - pharmacology Antioxidants - pharmacology Chemical properties Cholesterol - metabolism Composition Female Health aspects Hepatic Insufficiency - drug therapy Hepatic Insufficiency - enzymology Hepatic Insufficiency - metabolism Hepatic Insufficiency - parasitology Identification and classification Kidney - drug effects Kidney - metabolism Kidney - parasitology Leaves Lipid Metabolism - drug effects Liver - drug effects Liver - enzymology Liver - metabolism Liver - parasitology Malaria - drug therapy Malaria - metabolism Malaria - parasitology Malaria - pathology Male Materia medica, Vegetable Menispermaceae - chemistry Mice Nutritional aspects Oxidative Stress - drug effects Physiological aspects Phytochemistry Plant extracts Plant Extracts - pharmacology Plant Leaves - chemistry Plasmodium Plasmodium berghei - drug effects Random Allocation Sporozoites - drug effects
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Zusammenfassung:	Recent approach in treatment and drug development suggested that the control of oxidative stress in malarial infected patients may be an added advantage. In this study, effect of methanolic leaf extract of Sphenocentrum jollyanum pier (S. jollyanum) on liver damage, markers of oxidative stress and alteration in lipid profile in P. berghei infected mice was assessed. Oxidative stress was induced by intravenously inoculation of mice with 1 × 10⁷ sporozoites P. berghei. Treatment of parasitized mice with leaf extract of S. jollyanum had a significant (p
ISSN:	1011-601X