The relation between lymph node status and survival in Stage I-III colon cancer: results from a prospective nationwide cohort study

Aim This study involved a large nationwide Danish cohort to evaluate the hypothesis that a high lymph node harvest has a positive effect on survival in curative resected Stage I–III colon cancer and a low lymph node ratio has a positive effect on survival in Stage III colon cancer. Method Analysis o...

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Veröffentlicht in:	Colorectal disease 2013-05, Vol.15 (5), p.559-565
Hauptverfasser:	Lykke, J., Roikjær, O., Jess, P.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenocarcinoma - secondary Adenocarcinoma - surgery Aged Aged, 80 and over Colon cancer Colonic Neoplasms - pathology Colonic Neoplasms - surgery Denmark Female Humans Kaplan-Meier Estimate lymph node Lymph Node Excision Lymph Nodes - pathology Lymph Nodes - surgery Lymphatic Metastasis Male Middle Aged Neoplasm Staging Proportional Hazards Models Prospective Studies surgery survival Survival Rate
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Zusammenfassung:	Aim This study involved a large nationwide Danish cohort to evaluate the hypothesis that a high lymph node harvest has a positive effect on survival in curative resected Stage I–III colon cancer and a low lymph node ratio has a positive effect on survival in Stage III colon cancer. Method Analysis of overall survival was conducted using a nationwide Danish cohort of patients treated with curative resection of Stage I–III colon cancer. All 8901 patients in Denmark diagnosed with adenocarcinoma of the colon and treated with curative resection in the period 2003–2008 were identified from the Danish Colorectal Cancer Group (DCCG). The impact of lymph node count and lymph node ratio was analysed. Results Overall 5‐year survival was 56.8 and 66.6%, (P
ISSN:	1462-8910 1463-1318
DOI:	10.1111/codi.12059