Anti-apolipoprotein A-1 autoantibodies as biomarker for atherosclerosis burden in patients with periodontitis

Background and Objective Anti‐apolipoprotein A‐1 (anti‐apoA‐1) IgG is a potential marker of atherosclerotic plaque vulnerability and cardiovascular complications. In patients with periodontitis the presence of anti‐apoA‐1 IgGs in serum and their association with atherosclerosis is unknown. Material and Methods One‐hundred and thirty subjects with periodontal disease and 46 healthy subjects, matched for age and gender, participated in this study. Anti‐apoA‐1 IgG, high‐sensitivity C‐reactive protein (hsCRP) and matrix metalloproteinase (MMP) ‐2, ‐3, ‐8 and ‐9 were measured in serum samples. An ankle‐brachial index (ABI) value below 1.11 served as a surrogate marker of atherosclerosis. Predictive accuracies of biomarkers for abnormal ABI were determined using receiver–operating characteristics curves and logistic regression analyses. Results Compared with healthy controls, periodontitis patients showed lower median ABI values (1.10 vs. 1.15; p