Metal-based methods for protein inactivation

[Display omitted] ► The irreversible inactivation of protein targets by metal complexes is described. ► The article summaries catalysts that hydrolyze or oxidize proteins. ► Cyclen-based catalysts that selectively hydrolyze peptides and proteins are described. ► Catalysts that generate reactive oxygen species are important for protein inactivation. ► Metal-based oxidants are potent and selective agents for protein inactivation. Metal complexes are efficient catalysts for protein inactivation. Because of their special reactivity, metal-based molecules can achieve results that are difficult, if not impossible to obtain with more traditional, organic-based inhibitors. This article summarizes the chemistry of hydrolytic and oxidative catalysts for protein inactivation.