Hyrtimomines A–C, New Heteroaromatic Alkaloids from a Sponge Hyrtios sp

Three new alkaloids, hyrtimomines A–C (1–3), were isolated from an Okinawan marine sponge Hyrtios sp. The structures of 1–3 were elucidated on the basis of spectroscopic analysis and application of a phenylglycine methyl ester (PGME) method. Hyrtimomines A (1) and B (2) are heteroaromatic alkaloids...

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Veröffentlicht in:	Organic letters 2013-04, Vol.15 (8), p.2010-2013
Hauptverfasser:	Momose, Rei, Tanaka, Naonobu, Fromont, Jane, Kobayashi, Jun’ichi
Format:	Artikel
Sprache:	eng
Schlagworte:	Alkaloids - chemistry Alkaloids - isolation & purification Alkaloids - pharmacology Animals Antineoplastic Agents - chemistry Antineoplastic Agents - isolation & purification Antineoplastic Agents - pharmacology Drug Screening Assays, Antitumor Humans Japan KB Cells Leukemia L1210 Marine Biology Molecular Structure Oceans and Seas Porifera - chemistry Propylene Glycols - chemistry
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Beschreibung
Zusammenfassung:	Three new alkaloids, hyrtimomines A–C (1–3), were isolated from an Okinawan marine sponge Hyrtios sp. The structures of 1–3 were elucidated on the basis of spectroscopic analysis and application of a phenylglycine methyl ester (PGME) method. Hyrtimomines A (1) and B (2) are heteroaromatic alkaloids possessing a fused hexacyclic 6/5/6/6/7/5 ring system, while hyrtimomine C (3) is an alkaloid consisting of hydroxyindole and azepino-hydroxyindole moieties. Hyrtimomine A (1) exhibited cytotoxicity against KB and L1210 cells.
ISSN:	1523-7060 1523-7052
DOI:	10.1021/ol400687b