Asymmetric One-Pot Sequential Mannich/Hydroamination Reaction by Organo- and Gold Catalysts: Synthesis of Spiro[pyrrolidin-3,2′-oxindole] Derivatives

An asymmetric organo- and gold-catalyzed one-pot sequential Mannich/hydroamination reaction has been developed. Using this protocol, spiro[pyrrolidin-3,2′-oxindole] derivatives were synthesized in good yields (up to 91%) and excellent enantioselectivities (up to 97% ee).

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Veröffentlicht in:Organic letters 2013-04, Vol.15 (8), p.1846-1849
Hauptverfasser: Chen, Xianjie, Chen, Hui, Ji, Xun, Jiang, Hualiang, Yao, Zhu-Jun, Liu, Hong
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Sprache:eng
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Zusammenfassung:An asymmetric organo- and gold-catalyzed one-pot sequential Mannich/hydroamination reaction has been developed. Using this protocol, spiro[pyrrolidin-3,2′-oxindole] derivatives were synthesized in good yields (up to 91%) and excellent enantioselectivities (up to 97% ee).
ISSN:1523-7060
1523-7052
DOI:10.1021/ol4004542