A Map of Alzheimer's Disease-Signaling Pathways: A Hope for Drug Target Discovery

Alzheimer's disease (AD) is a complex neurodegenerative condition, and its drug therapy is challenging. To inform AD drug discovery, we developed the “AlzPathway,” a prototype of a comprehensive map of AD‐related signaling pathways, from information obtained through studies in the public domain...

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Veröffentlicht in:	Clinical pharmacology and therapeutics 2013-05, Vol.93 (5), p.399-401
Hauptverfasser:	Ogishima, S, Mizuno, S, Kikuchi, M, Miyashita, A, Kuwano, R, Tanaka, H, Nakaya, J
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult and adolescent clinical studies Alzheimer Disease - drug therapy Alzheimer Disease - physiopathology Biological and medical sciences Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases Drug Design Drug Discovery - methods Humans Medical sciences Molecular Targeted Therapy Neurology Organic mental disorders. Neuropsychology Pharmacology. Drug treatments Psychology. Psychoanalysis. Psychiatry Psychopathology. Psychiatry Signal Transduction Systems Biology
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Beschreibung
Zusammenfassung:	Alzheimer's disease (AD) is a complex neurodegenerative condition, and its drug therapy is challenging. To inform AD drug discovery, we developed the “AlzPathway,” a prototype of a comprehensive map of AD‐related signaling pathways, from information obtained through studies in the public domain. The AlzPathway provides an integrated platform for systems analyses of AD‐signaling pathways and networks. Clinical Pharmacology & Therapeutics (2013); 93 5, 399–401. doi:10.1038/clpt.2013.37
ISSN:	0009-9236 1532-6535
DOI:	10.1038/clpt.2013.37