Cu(II)-Promoted Palladium-Catalyzed C–H Ortho-Arylation of N,N‑Dimethylbenzylamines

A novel protocol for palladium-catalyzed arylation of the C­(sp2)–H bond directed by a N,N-dimethylaminomethyl group in the presence of AgOAc and Cu­(OAc)2·H2O is described. Various aryl iodides proved to be efficient coupling partners, furnishing the corresponding ortho monoarylated or diarylated arenes in moderate to good yields. Cu­(OAc)2·H2O is found to be the important additive to improve the yields in this transformation.