Genetic analysis of novel avian A(H7N9) influenza viruses isolated from patients in China, February to April 2013

Novel influenza viruses of the H7N9 subtype have infected 33 and killed nine people in China as of 10 April 2013. Their haemagglutinin (HA) and neuraminidase genes probably originated from Eurasian avian influenza viruses; the remaining genes are closely related to avian H9N2 influenza viruses. Seve...

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Veröffentlicht in:	Euro surveillance : bulletin européen sur les maladies transmissibles 2013-04, Vol.18 (15), p.20453-20453
Hauptverfasser:	Kageyama, T, Fujisaki, S, Takashita, E, Xu, H, Yamada, S, Uchida, Y, Neumann, G, Saito, T, Kawaoka, Y, Tashiro, M
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Birds Female Humans Influenza A Virus, H9N2 Subtype - isolation & purification Influenza A Virus, H9N2 Subtype - pathogenicity Influenza in Birds - diagnosis Influenza, Human - diagnosis Male Orthomyxoviridae Infections - transmission
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Zusammenfassung:	Novel influenza viruses of the H7N9 subtype have infected 33 and killed nine people in China as of 10 April 2013. Their haemagglutinin (HA) and neuraminidase genes probably originated from Eurasian avian influenza viruses; the remaining genes are closely related to avian H9N2 influenza viruses. Several characteristic amino acid changes in HA and the PB2 RNA polymerase subunit probably facilitate binding to human-type receptors and efficient replication in mammals, respectively, highlighting the pandemic potential of the novel viruses.
ISSN:	1560-7917