CtBP2 contributes to malignant development of human esophageal squamous cell carcinoma by regulation of p16INK4A

C‐terminal binding protein‐2 (CtBP2), as a transcriptional co‐repressor, has been shown to mediate the repression of p16INK4A, a tumor suppressor gene product, in primary human cells. Here we aimed to investigate how the correlation between CtBP2 and p16INK4A influenced the development of esophageal...

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Veröffentlicht in:	Journal of cellular biochemistry 2013-06, Vol.114 (6), p.1343-1354
Hauptverfasser:	Guan, Chengqi, Shi, Hui, Wang, Huijie, Zhang, Jianguo, Ni, Wenkai, Chen, Buyou, Hou, Sicong, Yang, Xiaojing, Shen, Aiguo, Ni, Runzhou
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Aged Aged, 80 and over Alcohol Oxidoreductases - physiology Antineoplastic Agents - pharmacology C-TERMINAL BINDING PROTEIN 2 (CtBP2) Carcinogenesis - genetics Carcinogenesis - metabolism Carcinoma, Squamous Cell - genetics Carcinoma, Squamous Cell - metabolism Carcinoma, Squamous Cell - mortality Cell Line, Tumor Cell Proliferation Cisplatin - pharmacology Cyclin-Dependent Kinase Inhibitor p16 - genetics Cyclin-Dependent Kinase Inhibitor p16 - metabolism Esophageal Neoplasms - genetics Esophageal Neoplasms - metabolism Esophageal Neoplasms - mortality Esophageal Squamous Cell Carcinoma ESOPHAGEAL SQUAMOUS CELL CARCINOMA (ESCC) Female Gene Expression Gene Expression Regulation, Neoplastic Humans Kaplan-Meier Estimate Male MALIGNANT DEVELOPMENT Middle Aged Nerve Tissue Proteins - physiology p16INK4A Prognosis
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Zusammenfassung:	C‐terminal binding protein‐2 (CtBP2), as a transcriptional co‐repressor, has been shown to mediate the repression of p16INK4A, a tumor suppressor gene product, in primary human cells. Here we aimed to investigate how the correlation between CtBP2 and p16INK4A influenced the development of esophageal squamous cell carcinoma (ESCC). Immunohistochemistry of ESCC tissue sections indicated that the CtBP2 and p16INK4A expressions were inversely correlated to each other with a linear regression coefficient of −0.747 (P
ISSN:	0730-2312 1097-4644
DOI:	10.1002/jcb.24475