Thienopyrrole-expanded BODIPY as a potential NIR photosensitizer for photodynamic therapy

The synthesis and characterization of a highly photostable bromo-substituted BODIPY dye (I) fused-ring-expanded with thienopyrrole moieties is reported. The results of MTT assays and flow cytometric analyses in living HeLa cells demonstrate that I has a high singlet oxygen quantum yield (ΦΔ = 0.63)...

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Veröffentlicht in:	Chemical communications (Cambridge, England) England), 2013-01, Vol.49 (38), p.3940-3942
Hauptverfasser:	Yang, Yongchao, Guo, Qiuli, Chen, Huachao, Zhou, Zhikuan, Guo, Zijian, Shen, Zhen
Format:	Artikel
Sprache:	eng
Schlagworte:	Boron Compounds - chemistry Boron Compounds - therapeutic use Cell Survival - drug effects Cell Survival - radiation effects HeLa Cells Humans Neoplasms - drug therapy Photochemotherapy - methods Photosensitizing Agents - chemistry Photosensitizing Agents - therapeutic use Pyrroles - chemistry Pyrroles - therapeutic use
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Beschreibung
Zusammenfassung:	The synthesis and characterization of a highly photostable bromo-substituted BODIPY dye (I) fused-ring-expanded with thienopyrrole moieties is reported. The results of MTT assays and flow cytometric analyses in living HeLa cells demonstrate that I has a high singlet oxygen quantum yield (ΦΔ = 0.63) and exhibits photocytotoxicity upon irradiation in the NIR region making it potentially suitable for use in PDT.
ISSN:	1359-7345 1364-548X
DOI:	10.1039/c3cc40746b