Treatment of acute carbon monoxide poisoning with extracorporeal membrane trioxygenation

OBJECTIVETo treat acute carbon monoxide poisoning (ACOP) with extracorporeal membrane trioxygenation (ECMO3), and to determine the efficacy and safety of ECMO3.METHODThirty-two New Zealand white rabbits were divided randomly into four groups including ECMO3 group (G1-ECMO3), oxygen treatment group (G2-FIO2), untreated ACOP group (G3-ACOP), and control group (G4-control). Rabbits in the first three groups were intraperitoneally injected with 99.99% CO at a dosage of 200 ml/kg, and those in the control group were treated with placebo. The dynamic changes in carboxyhemoglobin (COHb) concentration, blood oxygen saturation (SO2) level, base excess of blood (BE-B) as well as the vital signs of the rabbits were monitored.RESULTSAll the experimental rabbits had significantly higher levels of COHb (p = 0.000