Glucocorticoid regulation of brain-derived neurotrophic factor: Relevance to hippocampal structural and functional plasticity

Glucocorticoid regulation of brain-derived neurotrophic factor: Relevance to hippocampal structural and functional plasticity

Graphical abstract Highlights ► Glucocorticoids and BDNF exert opposing effects on hippocampal plasticity. ► Glucocorticoids modulate BDNF transcription and signaling at multiple levels. ► Reciprocal crosstalk between glucocorticoids and BDNF signaling pathways.

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Veröffentlicht in:Neuroscience 2013-06, Vol.239, p.196-213
Hauptverfasser: Suri, D, Vaidya, V.A
Format: Artikel
Sprache:eng
Schlagworte:
Brain-Derived Neurotrophic Factor - metabolism
glucocorticoid receptor
Glucocorticoids - metabolism
Hippocampus - cytology
Hippocampus - metabolism
hormone
Humans
mitogen-activated protein kinase
Neurology
Neuronal Plasticity - physiology
neurotrophin
Signal Transduction - physiology
stress
tropomyosin-related kinase B
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Zusammenfassung:Graphical abstract Highlights ► Glucocorticoids and BDNF exert opposing effects on hippocampal plasticity. ► Glucocorticoids modulate BDNF transcription and signaling at multiple levels. ► Reciprocal crosstalk between glucocorticoids and BDNF signaling pathways.
ISSN:0306-4522
1873-7544
DOI:10.1016/j.neuroscience.2012.08.065