Small-molecule inhibitors of cathepsin L incorporating functionalized ring-fused molecular frameworks

Cathepsin L is a cysteine protease that is upregulated in a variety of malignant tumors and plays a significant role in cancer cell invasion and migration. It is an attractive target for the development of small-molecule inhibitors, which may prove beneficial as treatment agents to limit or arrest c...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Bioorganic & medicinal chemistry letters 2013-05, Vol.23 (9), p.2801-2807
Hauptverfasser:	Song, Jiangli, Jones, Lindsay M., Chavarria, Gustavo E., Charlton-Sevcik, Amanda K., Jantz, Adam, Johansen, Audra, Bayeh, Liela, Soeung, Victoria, Snyder, Lindsey K., Lade, Shawn D., Chaplin, David J., Trawick, Mary Lynn, Pinney, Kevin G.
Format:	Artikel
Sprache:	eng
Schlagworte:	benzophenone carbon cathepsin B Cathepsin B - antagonists & inhibitors Cathepsin B - metabolism Cathepsin L Cathepsin L - antagonists & inhibitors Cathepsin L - metabolism cell invasion Chemical synthesis Chromans - chemistry Enzyme inhibition inhibitory concentration 50 metastasis neoplasms nitrogen oxygen Protease Inhibitors - chemical synthesis Protease Inhibitors - chemistry Protease Inhibitors - metabolism Protein Binding Quinolines - chemistry Safrole - analogs & derivatives Safrole - chemistry Small Molecule Libraries - chemical synthesis Small Molecule Libraries - chemistry Small Molecule Libraries - metabolism Small-molecule inhibitors Structure-Activity Relationship structure-activity relationships Sulfones - chemistry sulfur Tetrahydronaphthalenes - chemistry
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!