Polysaccharide-lecithin reverse micelles with enzyme-degradable triglyceride shell for overcoming tumor multidrug resistance

A newly-designed drug carrier with enzyme-triggered release behavior and the ability to circumvent multidrug resistance was successfully developed. By optimizing the ratio of lecithin and polysaccharide in reverse micelles, encapsulation efficiency and encapsulation stability can be significantly im...

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Veröffentlicht in:	Chemical communications (Cambridge, England) England), 2013-05, Vol.49 (36), p.3772-3774
Hauptverfasser:	Su, Chia-Wei, Chen, San-Yuan, Liu, Dean-Mo
Format:	Artikel
Sprache:	eng
Schlagworte:	Cell Survival - drug effects Chitosan - chemistry Doxorubicin - chemistry Doxorubicin - toxicity Drug Carriers - chemistry Drug Resistance, Neoplasm Humans Hydrolysis Lecithins - chemistry MCF-7 Cells Micelles Nanoparticles - chemistry Polysaccharides - chemistry Sterol Esterase - metabolism Triglycerides - chemistry Triglycerides - metabolism
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Beschreibung
Zusammenfassung:	A newly-designed drug carrier with enzyme-triggered release behavior and the ability to circumvent multidrug resistance was successfully developed. By optimizing the ratio of lecithin and polysaccharide in reverse micelles, encapsulation efficiency and encapsulation stability can be significantly improved.
ISSN:	1359-7345 1364-548X
DOI:	10.1039/c3cc40836a